Long non-coding RNA FTH1P3 facilitates oral squamous cell carcinoma progression by acting as a molecular sponge of miR-224-5p to modulate fizzled 5 expression

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• 作者：Chen-Zheng Zhang ; ^{zhangchenzheng@whu.edu.cn}
• 关键词：lncRNAs ; long noncoding RNAs ; OSCC ; oral squamous cell carcinoma ; EMT ; epithelial-to-mesenchymal transition ; FTH1P3 ; ferritin heavy chain 1 pseudogene 3 ; ceRNA ; competing endogenous RNAs ; miR-224-5p ; hsa-miRNA-224-5p ; ANOVA ; One-Way Analysis of Variance
• 刊名：Gene
• 出版年：2017
• 出版时间：5 April 2017
• 年：2017
• 卷：607
• 期：Complete
• 页码：47-55
• 全文大小：1302 K
• 卷排序：607

文摘

FTH1P3 is up-regulated in human primary OSCC tissues. Expression of fizzled 5 is up-regulated in primary human OSCC and negatively expressed related to miR-224-5p. miR-224-5p inhibits the tumorigenic potential of OSCC cells by down-regulating oncogenic FZD5 gene. FTH1P3′s oncogenic functions are partially through reverse regulation of miRNA-224-5p, and then activation of fizzled 5.