Anti-colitis effect of Lactobacillus sakei K040706 via suppression of inflammatory responses in the dextran sulfate sodium-induced colitis mice model

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• 作者：Seunghwan Seo^a ; ^b ; ¹ ; Ji-Sun Shin^a ; ¹ ; Woo-Seok Lee^a ; ^b ; Young Kyoung Rhee^c ; Chang-Won Cho^c ; Hee-Do Hong^c ; Kyung-Tae Lee^a ; ^b ; ^{ktlee@khu.ac.kr}
• 关键词：DSS ; dextran sulfate sodium ; IBD ; inflammatory bowel disease ; ICAM ; intracellular adhesion molecule ; IL-1β ; interleukin-1β ; IL-6 ; interleukin-6 ; iNOS ; inducible nitric oxide synthase ; MPO ; myeloperoxidase ; NF-κB ; nuclear factor-kappa B ; STAT3 ; signal transducer and activator of transcription 3 ; TLR4 ; toll-like receptor 4 ; TNF-α ; tumor necrosis factor-α ; VCAM ; vascular cell adhesion molecule
• 刊名：Journal of Functional Foods
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：29
• 期：Complete
• 页码：256-268
• 全文大小：2417 K
• 卷排序：29

文摘

K040706 attenuated DSS-induced colitis severity and epithelial injury. K040706 suppressed the DSS-induced expression of pro-inflammatory mediators. K040706 downregulated the DSS-induced activation of TLR4/NF-κB/STAT3 signaling. K040706 improved the intestinal microbiota composition. K040706 has potential as a treatment option for inflammatory bowel disease.