Altered expression of miRNAs in the uterus from a letrozole-induced rat PCOS model

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• 作者：Chunjin Li^a ; Lu Chen^a ; Yun Zhao^a ; Shuxiong Chen^a ; Lulu Fu^b ; Yanwen Jiang^a ; Shan Gao^a ; Zhuo Liu^a ; Fengge Wang^a ; Xiaoling Zhu^a ; Jiahui Rao^a ; Jing Zhang^a ; Xu Zhou^a ; ^{xzhou65@vip.sina.com}
• 关键词：PCOS ; polycystic ovary syndrome ; qRT-PCR ; quantitative RT-PCR ; COG ; Cluster of Orthologous Groups ; KEGG ; Kyoto Encyclopedia of Genes and Genomes ; SPSS ; Statistical Package for Social Sciences ; MAPK ; mitogenactivated protein kinase ; PI3K-Akt ; phosphoinositide 3-kinase/Akt ; IRS-1 and IRS-2 ; insulin receptor substrate 1&ndash ; 2
• 刊名：Gene
• 出版年：2017
• 出版时间：20 January 2017
• 年：2017
• 卷：598
• 期：Complete
• 页码：20-26
• 全文大小：1326 K
• 卷排序：598

文摘

A total of 148 miRNAs were differentially expressed in the uterus from letrozole-induced rat model compared with the control. The differentially expressed miRNAs were predicted to target a large set of genes with different functions. Pathway analysis supported that these miRNAs were involved in different signaling pathways. MiRNAs differentially expressed in rat uterus with PCOS might be involved in the etiology and pathophysiology in the uterus of PCOS.