Endogenously synthesized n-3 polyunsaturated fatty acids in fat-1 transgenic mice suppress B16F10 melanoma lung metastasis by impairing mesenchymal to epithelial transition

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• 作者：Pan Zhu^a ; ¹ ; Yuan-Ming Zhang^a ; ¹ ; Xuan Yin^b ; Xiao-Hong Zhang^a ; Feng Wang^c ; Jin-Jie Zhang^d ; Wang Yan^e ; Yang Xi^a ; Jian-Bo Wan^f ; Jing-Xuan Kang^g ; Zu-Quan Zou^a ; ¹ ; ^{zouzuquan@nbu.edu.cn} ; Shi-Zhong Bu^a ; ¹ ; ^{bushizhong@nbu.edu.cn}
• 关键词：Fat-1 ; n-3 polyunsaturated fatty acids ; Mesenchymal to epithelial transition ; Lipid mediators ; IL-1β ; Melanoma
• 刊名：Journal of Functional Foods
• 出版年：2016
• 出版时间：December 2016
• 年：2016
• 卷：27
• 期：Complete
• 页码：483-490
• 全文大小：1319 K
• 卷排序：27

文摘

Endogenous n-3 polyunsaturated fatty acids (PUFA) inhibited lung metastases of B16F10 melanoma cells in fat-1 transgenic mice. The anti-inflammatory status of n-3 PUFAs contributes to lung metastasis inhibition of melanoma cells by impairing MET.