Intergenic variants may predispose to major depression disorder through regulation of long non-coding RNA expression

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• 作者：Ning Ye ; Shuquan Rao ; Tingfu Du ; Huiling Hu ; Zeyue Liu ; Yan Shen ; Qi Xu ; ^{xuqi@pumc.edu.cn}
• 关键词：GWA studies ; genome-wide association studies ; SNP ; single nucleotide polymorphism ; MDD ; major depressive disorder ; TAS ; trait/disease-associated SNP ; lncRNA ; long noncoding RNA ; DSM-IV ; Diagnostic and Statistical Manual of Mental Disorders Fourth Edition ; HAMD-17 ; 17-item Hamilton Rating Scale for Depression ; χ2 ; chi-square ; HWE ; Hardy&ndash ; Weinberg equilibrium ; FC ; fold change ; MAF ; minor allele frequency ; LncRNA Disease ; LncRNA And Disease Database ; BDNF-AS ; brain-derived neurotrophic factor
• 刊名：Gene
• 出版年：2017
• 出版时间：15 February 2017
• 年：2017
• 卷：601
• 期：Complete
• 页码：21-26
• 全文大小：610 K
• 卷排序：601

文摘

We provide preliminary evidence that intergenic variants might contribute to the pathogenesis of MDD through regulating the expression of lncRNAs where these variants are located. We identified two lncRNA genes for MDD susceptibility, namely LINC01108 and LINC00998. Non-coding variants may play an important role in conferring risk of MDD.