Synthesis of [1,2,3]-triazolo[1,5-a][1,4]benzodiazepines via an unprecedented one-pot Cu-catalyzed azidation-cyclization reaction

详细信息    查看全文

• 作者：Geert Hooyberghs ; Hendrik De Coster ; Dipak D. Vachhani ; Denis S. Ermolat'ev ; Erik V. Van der Eycken ; ^{erik.vandereycken@chem.kuleuven.be}
• 关键词：Medium-sized ring ; Benzodiazepine ; Tandem reaction
• 刊名：Tetrahedron
• 出版年：2013
• 出版时间：27 May, 2013
• 年：2013
• 卷：69
• 期：21
• 页码：4331-4337
• 全文大小：382 K

文摘

A novel three-step approach leading to [1,2,3]-triazolo[1,5-a][1,4]benzodiazepines in moderate to good yields has been developed. The key step is an unprecedented one-pot Cu-catalyzed azidation-cyclization reaction of ortho-bromobenzylpropargylamines.