Enantioselective direct fluorination and chlorination of cyclic ¦Â-ketoesters mediated by phase-transfer catalysts

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• 作者：Jie Luo^a ; ^&dagger ; ; Wenqin Wu^a ; Li-Wen Xu^b ; Yuezhong Meng^c ; ^{mengyzh@mail.sysu.edu.cn} ; Yixin Lu^a ; ^b ; ^{chmlyx@nus.edu.sg}
• 关键词：Fluorination ; Chlorination ; Phase-transfer catalysis (PTC) ; ketoesters
• 刊名：Tetrahedron Letters
• 出版年：2013
• 出版时间：22 May, 2013
• 年：2013
• 卷：54
• 期：21
• 页码：2623-2626
• 全文大小：1531 K

文摘

A straightforward and practical method for the direct fluorination and chlorination of various ¦Â-ketoesters employing a phase-transfer catalyst is developed. The desired products with fluorine/chlorine-substituted quaternary chiral centers are prepared with good to excellent enantioselectivities.