We conducted a meta-analysis on two genetic variants (RANTES-403 G/A and CCR5¦¤32). Publication bias was tested by the Egger's regression test and Begg's test. Sensitivity analysis and subgroup analyses were performed to explore the heterogeneity among studies.
No significant association of RANTES-403 G/A polymorphism and CAD risk was observed (dominant model: RR = 1.02, 95 % CI = 0.90-1.06; recessive model: RR = 1.27, 95 % CI = 0.90-1.80). However, after excluding the study conducted by Yangsoo et al., the pooled relative ratio (RR) in the dominant model suggested that the RANTES-403 G/A polymorphism was positively associated with CAD risk. The subgroup analyses found that a positive relationship between the polymorphism and CAD risk was restricted to the Caucasian population. A meta-analysis of studies on the CCR5¦¤32 polymorphism showed no significant association with CAD risk both in dominant (RR = 1.05, 95 % CI = 0.92-1.21) and recessive (RR = 1.27, 95 % CI = 0.90-1.80) models. Moreover, no association was identified in the subgroup analyses.
The RANTES-403 G/A polymorphism is not associated with CAD risk, but does most likely increase CAD risk in Caucasians. Moreover, no relationship between the CCR5?32 polymorphism and risk of CAD was found.
© 2004-2018 中国地质图书馆版权所有 京ICP备05064691号 京公网安备11010802017129号 地址:北京市海淀区学院路29号 邮编:100083 电话:办公室:(+86 10)66554848;文献借阅、咨询服务、科技查新:66554700 |