Integration of Biomass Formulations of Genome-Scale Metabolic Models with Experimental Data Reveals Universally Essential Cofactors in Prokaryotes

详细信息    查看全文

• 作者：Joana C. Xavier^a ; ^b ; ^{joanarcxavier@ceb.uminho.pt} ; Kiran Raosaheb Patil^b ; ^{patil@embl.de} ; Isabel Rocha^a ; ^{irocha@deb.uminho.pt}
• 关键词：NAD+(PubChem CID ; 5892) ; NADP+(PubChem CID ; 5886) ; S-adenosylmethionine (PubChem CID ; 34755) ; Flavin Adenine Dinucleotide (PubChem CID ; 643975) ; Pyridoxal 5&prime ; -phosphate (PubChem CID ; 1051) ; Coenzyme A (PubChem CID ; 87642) ; Tetrahydrofolate (PubChem CID ; 91443) ; Tetrahydromethanopterin (PubChem CID ; 5462234) ; Thiamine diphosphate (PubChem CID ; 1132) ; Flavin mononucleotide (PubChem CID ; 643976)
• 刊名：Metabolic Engineering
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：39
• 期：Complete
• 页码：200-208
• 全文大小：1714 K
• 卷排序：39

文摘

Seventy one biomass equations of manually curated genome-scale metabolic models are compared. Eight classes of universally essential prokaryotic organic cofactors are proposed. Conditionally essential organic cofactors are presented and discussed. Gene essentiality predictions for Klebsiella pneumoniae are revised. A missing essential pathway in models of Mycobacterium tuberculosis is predicted.