Synthesis and biological evaluation of novel hydroxybenzaldehyde-based kojic acid analogues as inhibitors of mushroom tyrosinase

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• 作者：Wenlin Xie^a ; ^b ; ^c ; ^{xwl99zsu@163.com} ; Huilin Zhang^a ; Jingjing He^a ; Jingai Zhang^a ; Qiuyan Yu^a ; Chunxiang Luo^a ; Shangru Li^a
• 关键词：Kojic acid ; Tyrosinase inhibitors ; Benzaldehyde ; 1 ; 2 ; 4-Triazole
• 刊名：Bioorganic & Medicinal Chemistry Letters
• 出版年：2017
• 出版时间：1 February 2017
• 年：2017
• 卷：27
• 期：3
• 页码：530-532
• 全文大小：431 K
• 卷排序：27

文摘

Two series of novel kojic acid analogues were synthesized. All newly synthesized compounds were screened for tyrosinase inhibitory activity. Most of the prepared compounds exhibited significant inhibitory activity of tyrosinase in vitro. The structure-activity relationship was discussed.