Synthesis, characterization and antibacterial activity of novel heterocyclic quaternary ammonium surfactants

详细信息    查看全文

• 作者：Mahantesh Jadhav ; Rahul S. Kalhapure ; ^{kalhapure@ukzn.ac.za} ; ^{rahul.kalhapure@rediffmail.com} ; Sanjeev Rambharose ; Chunderika Mocktar ; Thirumala Govender ; ^{govenderth@ukzn.ac.za}
• 关键词：Heterocyclic ; Quaternary ammonium ; Cationic surfactants ; Synthesis ; Antibacterial activity
• 刊名：Journal of Industrial and Engineering Chemistry
• 出版年：2017
• 出版时间：25 March 2017
• 年：2017
• 卷：47
• 期：Complete
• 页码：405-414
• 全文大小：1722 K
• 卷排序：47

文摘

This work reports two new classes of non-toxic heterocyclic quaternary ammonium surfactants (HQASs) synthesized by condensation of a series of fatty acids with 2-morpholinoethan-1-amine and pyridin-4-ylmethanamine, followed by quaternization with benzyl bromide. Their critical micelle concentration (CMC), Krafft temperature (Tk), emulsion stability and foaming properties were determined. The CMC values of HQASs ranged from 0.24 to 0.55 mM/L. In vitro antibacterial activity studies revealed that the HQASs possessing unsaturated hydrocarbon chains exhibited activity against all the tested bacteria (minimum inhibitory concentration = 31.25–500 μg/mL) whereas, those possessing saturated hydrocarbon chains did not exhibit any activity.