Investigation of cellular response to covalent immobilization of peptide and hydrophobic attachment of peptide amphiphiles on substrates

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• 作者：Fahimeh Shamsi^a ; ^b ; ^{fahimeh.shamsi@ymail.com}
• 关键词：RGD peptide ; Lipidated peptide ; Silicon surface ; Covalent immobilization ; Cell response ; Alkyl tail
• 刊名：Biochemical Engineering Journal
• 出版年：2017
• 出版时间：15 January 2017
• 年：2017
• 卷：117
• 期：part_PB
• 页码：82-88
• 全文大小：2276 K
• 卷排序：117

文摘

Two types of surface were designed. In one of them, RGD peptide was covalently immobilized on silicon surfaces. The lipidated version of RGD peptide was hydrophobically attached on alkylated surfaces. Cellular response of all modified surfaces was examined. Hydrophobically attached lipidated RGD peptide increased cellular response significantly.