Association of interleukin-13 SNP rs20541 with allergic rhinitis risk: A meta-analysis

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• 作者：Xin-Jiang Ying^a ; ^{yingxinjiang@126.com} ; Shu-Wei Zhao^b ; ^{zhaoshw1@yahoo.com.cn} ; Guo-Liang Wang^a ; Jin Xie^a ; Hong-Ming Xu^a ; Pin Dong^a ; ^{dongpin64@yahoo.com.cn}
• 关键词：IL-13 ; interleukin-13 ; AR ; allergic rhinitis ; OR ; odds ratio ; CI ; Confidence interval
• 刊名：Gene
• 出版年：2013
• 出版时间：1 June, 2013
• 年：2013
• 卷：521
• 期：2
• 页码：222-226
• 全文大小：335 K

文摘

Studies investigating the association between interleukin-13 (IL-13) single nucleotide polymorphism (SNP) rs20541 and allergic rhinitis (AR) risk have reported conflicting results. The aim of the present study was to conduct a meta-analysis assessing the possible association of IL-13 SNP rs20541 with AR risk. Eight studies were included in the present meta-analysis (2153 cases and 3931 controls). The combined results based on all studies showed that IL-13 SNP rs20541 was associated with increased AR risk (Gln versus Arg: odds ratio (OR) = 1.18, 95 % confidence interval (CI) = 1.08-1.30; Gln/Gln versus Arg/Arg: OR = 1.52, 95 % CI = 1.20-1.92; Arg/Gln + Gln/Gln versus Arg/Arg: OR = 1.19, 95 % CI = 1.06-1.33; Gln/Gln versus Arg/Gln + Arg/Arg: OR = 1.42, 95 % CI = 1.13-1.79). When stratifying for race, IL-13 SNP rs20541 exhibited increased AR risk in Asians (Gln versus Arg: OR = 1.20, 95 % CI = 1.06-1.36; Gln/Gln versus Arg/Arg: OR = 1.57, 95 % CI = 1.17-2.12; Arg/Gln + Gln/Gln versus Arg/Arg: OR = 1.22, 95 % CI = 1.04-1.44; Gln/Gln versus Arg/Gln + Arg/Arg: OR = 1.45, 95 % CI = 1.09-1.93), while no significant association was detected in Caucasians (Gln versus Arg: OR = 1.28, 95 % CI = 0.93 ~ 1.78; Gln/Gln versus Arg/Arg: OR = 1.42, 95 % CI = 0.96-2.11; Arg/Gln + Gln/Gln versus Arg/Arg: OR = 1.35, 95 % CI = 0.89-2.05; Gln/Gln versus Arg/Gln + Arg/Arg: OR = 1.37, 95 % CI = 0.93-2.02). This meta-analysis supported that IL-13 SNP rs20541 was associated with AR, particularly in Asians.