Fabrication and characterization of conductive poly (3,4-ethylenedioxythiophene) doped with hyaluronic acid/poly (l-lactic acid) composite film for biomedical application

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• 作者：Shuping Wang¹ ; Shui Guan¹ ; ^{guanshui@dlut.edu.cn} ; Jing Wang¹ ; Hailong Liu² ; Tianqing Liu¹ ; Xuehu Ma¹ ; Zhanfeng Cui³
• 关键词：Poly 3 ; 4-ethylenedioxythiophene-hyaluronic acid/poly(l-lactic acid) composite film ; Conducting polymer ; PC12 cells ; Neurite outgrowth ; Electrical stimulation
• 刊名：Journal of Bioscience and Bioengineering
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：123
• 期：1
• 页码：116-125
• 全文大小：2354 K
• 卷排序：123

文摘

Conductive HA-doped PEDOT nanoparticles were synthesized by chemical oxidative polymerization. The prepared PEDOT-HA/PLLA films could support PC12 cells' adhesion, survival and spread, compared with pure PLLA films. PC12 cells on PEDOT-HA/PLLA films displayed longer neurite and higher mRNA expression levels of GAP43 and SYP, under 0.5 mA current stimulation.