Nano polyelectrolyte complexes of carboxymethyl dextran and chitosan to improve chitosan-mediated delivery of miR-145

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• 作者：Farnaz Sadat Mirzazadeh Tekie^a ; Melika Kiani^b ; Amir Zakerian^c ; Faezeh Pilevarian^a ; Akram Assali^b ; Masoud Soleimani^d ; ^e ; Rassoul Dinarvand^a ; ^b ; Ehsan Arefian^d ; ^f ; Amir Atashi^g ; Mohsen Amini^h ; Fatemeh Atyabi^a ; ^b ; ^{atyabifa@tums.ac.ir}
• 关键词：PEC ; polyelecrolyte complexe ; Ch ; chitosan ; CMD ; carboxymethyl dextran ; miR-145 ; micro RNA-145 ; Mw ; molecular weight ; Mn ; molecular number ; FBS ; fetal bovine serum ; PDI ; polydispersity index ; DMEM ; Dulbecco&rsquo ; s modified Eagle&rsquo ; s medium ; DLS ; dynamic light scattering ; DSC ; differential scanning colorimetery ; IR ; infra-red ; TEM ; transmission electron microscopy ; GFP ; green fluorescent protein ; PBS ; phosphate buffer solution ; SD ; standard deviation ; ANOVA ; one-way analysis of variance
• 刊名：Carbohydrate Polymers
• 出版年：2017
• 出版时间：1 March 2017
• 年：2017
• 卷：159
• 期：Complete
• 页码：66-75
• 全文大小：1877 K
• 卷排序：159

文摘

PEC stability and dissociation rate are crucial factors for gene delivery. PEC preparation method affect its characteristics including size distribution. Depending to Ch Mw and CMD:Ch ratio, nano PECs are efficient gene delivery systems.