Novel dual stimuli-responsive ABC triblock copolymer: RAFT synthesis, “schizophrenic” micellization, and its performance as an anticancer drug delivery nanosystem

详细信息    查看全文

• 作者：Soodabeh Davaran^a ; ^b ; ¹ ; Aliyeh Ghamkhari^c ; ¹ ; Effat Alizadeh^d ; Bakhshali Massoumi^c ; ^{b_massoumi@pnu.ac.ir} ; ^{bakhshalim@yahoo.com} ; Mehdi Jaymand^e ; ^{m_jaymand@yahoo.com} ; ^{m.jaymand@gmail.com} ; ^{jaymandm@tbzmed.ac.ir}
• 关键词：RAFT polymerization ; Triblock copolymer ; Self-assembly ; &ldquo ; Schizophrenic&rdquo ; Stimuli-responsive ; Enhanced drug delivery
• 刊名：Journal of Colloid and Interface Science
• 出版年：2017
• 出版时间：15 February 2017
• 年：2017
• 卷：488
• 期：Complete
• 页码：282-293
• 全文大小：2069 K
• 卷排序：488

文摘

A novel pH- and thermo-responsive ABC triblock copolymer was successfully synthesized. The “schizophrenic” self-assembly behavior of copolymer was fully investigated. The biocompatibility of the synthesized triblock copolymer was evaluated by MTT assay. Apoptosis inducing properties of DOX-loaded copolymer was examined using DAPI staining assay. This copolymer was successfully applied for enhanced delivery of DOX as an anticancer drug.