Green synthesis of novel spiro[indoline-3,4′-pyrazolo[3,4-b]pyridine]-2,3′(7′pan style='font-style: italic'>H)- dione, spiro[indeno[1,2-b]pyrazolo[4,3-e]pyridine-4,3′-indoline]-2′,3-dione, and spiro[benzo [h]pyrazolo[3,4-b]quinoline-7,3′-indoline]-2′,8(5H)-dione derivatives in aqueous medium

详细信息    查看全文

• 作者：Zhansheng Wang ; Lingli Gao ; Zhongyun Xu ; Zhi Ling ; Yaqi Qin ; Liangce Rong ; ^{lcrong@jsnu.edu.cn} ; Shu-Jiang Tu
• 关键词：Pyrazolo[3 ; 4-b]pyridine ; Pyrazolo[4 ; 3-e]pyridine ; Pyrazolo[3 ; 4-b]quinoline ; Aqueous medium ; Green synthesis
• 刊名：Tetrahedron
• 出版年：2017
• 出版时间：26 January 2017
• 年：2017
• 卷：73
• 期：4
• 页码：385-394
• 全文大小：420 K
• 卷排序：73

文摘

The green synthesis of novel spiro[indoline-3,4′-pyrazolo[3,4-b]pyridine]- 2,3′(7′H)-dione, spiro[indeno[1,2-b]pyrazolo[4,3-e]pyridine-4,3′-indoline]-2′,3-dione, and spiro[benzo[h]pyrazolo[3,4-b]quinoline-7,3′-indoline]-2′,8(5H)-dione derivatives was reported. The reactions were carried out smoothly in water in the presence of acetic acid with high yields. Some products could be obtained by direct filtration from the water without further purification. The advantages of this approach were simple operation, mild reaction conditions, easy isolation, and wide scope substrates. Most important of all, this reaction process is green.