Evaluation of folic acid tagged aminated starch/ZnO coated iron oxide nanoparticles as targeted curcumin delivery system

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• 作者：Chinmayee Saikia^a ; Monoj K. Das^b ; Anand Ramteke^b ; Tarun K. Maji^a ; ^{tkm@tezu.ernet.in}
• 关键词：Aminated starch ; Iron oxide ; Zinc oxide ; Drug delivery
• 刊名：Carbohydrate Polymers
• 出版年：2017
• 出版时间：10 February 2017
• 年：2017
• 卷：157
• 期：Complete
• 页码：391-399
• 全文大小：3756 K
• 卷排序：157

文摘

ZnO incorporated aminated starch coated iron oxide nanoparticles were prepared for targeted delivery of the anticancer agent, curcumin. The prepared nanoparticles showed significant in vitro controlled release of curcumin. The nanoparticles were compatible with human lymphocytes while showed inhibitory effect on cancer cells. Folic acid tagging to the nanoparticles resulted into enhanced cellular uptake along with significant ROS generations.