Patients with MS and group age- and sex-matched controls underwent high-resolution diffusion scanning (1-mm isotropic voxels) and cognitive testing. Manually drawn forniceal regions of interest were applied to individual maps of tensor-derived measures, and mean values of transverse diffusivity (TD), mean diffusivity (MD), longitudinal diffusivity (LD) and fractional anisotropy (FA) were calculated.
In 40 patients with MS [mean age¡ÀS.D.= 42.55¡À9.1 years; Expanded Disability Status Scale (EDSS)=2.0¡À1.2; Multiple Sclerosis Functional Composite (MSFC) score=0.38¡À0.46] and 20 healthy controls (mean age¡ÀS.D.= 41.35¡À9.7 years; EDSS=0.0¡À0; MSFC score=0.74¡À0.24), we found that FA, MD and TD values in the fornix were significantly different between groups (P< .03), and patient performance on the Brief Visuospatial Memory Test-Revised (BVMT-R) was correlated with DTI measures (P< .03).
These results are consistent with findings of axonal degeneration in MS and support the use of DTI as an indicator of disease progression.
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