Dual pH/redox responsive and CD44 receptor targeting hybrid nano-chrysalis based on new oligosaccharides of hyaluronan conjugates

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• 作者：Daquan Chen ; ^{cdq1981@126.com} ; Xue Dong ; Mengjiao Qi ; Xiaoyan Song ; Jingfang Sun
• 关键词：Dual pH/redox responsive ; Multifunctional nanoparticles ; Bioinspired prodrug ; Smart drug delivery ; Oligosaccharides of hyaluronan
• 刊名：Carbohydrate Polymers
• 出版年：2017
• 出版时间：10 February 2017
• 年：2017
• 卷：157
• 期：Complete
• 页码：1272-1280
• 全文大小：2330 K
• 卷排序：157

文摘

We designed a dual pH/redox responsive menthone ketal (oHSMC) based oligosaccharides of hyaluronan (oHA) conjugate. We developed a novel loaded curcumin (Cur) nano-chrysalis inspired by butterfly pupa with oHSMC and inorganic CaP. The nano-chrysalis has an inner core composed of specially designed oHA targeting CD44 receptor. The nano-chrysalis could release encapsulated curcumin with accelerated rate under lower pH and redox condition. The nano-chrysalis was less toxic and suppressed tumor growth most efficiently.