3-Aroylindoles display antitumor activity in vitro and in vivo: Effects of N1-substituents on biological activity

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• 作者：Hsueh-Yun Lee^a ; Jiann-Fong Lee^a ; Sunil Kumar^a ; Yi-Wen Wu^b ; Wei-Chun HuangFu^c ; Mei-Jung Lai^d ; Yu-Hsuan Li^a ; Hsiang-Ling Huang^a ; Fei-Chiao Kuo^a ; Che-Jen Hsiao^e ; Chun-Chun Cheng^c ; Chia-Ron Yang^b ; ^{cryang@ntu.edu.tw} ; Jing-Ping Liou^a ; ^{jpl@tmu.edu.tw}
• 关键词：Anticancer agents ; Histone deacetylase inhibitors ; 3-Aroylindoles ; Tubulin polymerization inhibition
• 刊名：European Journal of Medicinal Chemistry
• 出版年：2017
• 出版时间：5 January 2017
• 年：2017
• 卷：125
• 期：Complete
• 页码：1268-1278
• 全文大小：2013 K
• 卷排序：125

文摘

A series of 3-aroylindole were designed and synthesized. One compound (12) with potent antiproliferative activity was identified. Compounds 12 was potent to selectively inhibit HDAC6 and showed antitubulin activity.