Metabonomics study of the therapeutic mechanism of fenugreek galactomannan on diabetic hyperglycemia in rats, by ultra-performance liquid chromatography coupled with quadrupole time-of-flight mass spectrometry

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• 作者：Wenyue Jiang^a ; ^b ; ^c ; Lu Gao^b ; Pengdong Li^d ; Hong Kan^e ; Jiale Qu^b ; Lihui Men^a ; Zhiqiang Liu^c ; Zhongying Liu^a ; ^{liuzy@jlu.edu.cn}
• 关键词：Fenugreek galactomannan ; Metabonomics ; Therapeutic mechanism ; Diabetes ; Ultra-performance liquid chromatography coupled with quadrupole time-of-flight mass spectrometry
• 刊名：Journal of Chromatography B
• 出版年：2017
• 出版时间：15 February 2017
• 年：2017
• 卷：1044-1045
• 期：Complete
• 页码：8-16
• 全文大小：1424 K
• 卷排序：1044

文摘

UPLC-QTOF/MS-based metabonomics approach was applied to study the therapeutic mechanism underlying F-GAL in diabetes. Fourteen potential biomarkers were identified. Such as urocanic acid, citric acid, hippuric acid, arachidonic acid, and so on. F-GAL was elucidated to be a potential therapeutic agent for the treatment of diabetes via multiple therapeutic mechanisms.