Simultaneous determination and pharmacokinetic study of four phenolic acids in rat plasma using UFLC-MS/MS after intravenous administration of salvianolic acid for injection

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• 作者：Xiuman Xie^a ; ¹ ; Jingzhuo Miao^a ; ¹ ; Wanyang Sun^a ; Jingyi Huang^b ; Dongxiang Li^b ; Shuming Li^b ; Ling Tong^b ; ^{tongling@tasly.com} ; Guoxiang Sun^a ; ^{gxswmwys@163.com}
• 关键词：Salvianolic acid for injection ; Ultra-fast liquid chromatography-tandem mass spectrometry ; Pharmacokinetics ; Protein precipitation
• 刊名：Journal of Pharmaceutical and Biomedical Analysis
• 出版年：2017
• 出版时间：5 February 2017
• 年：2017
• 卷：134
• 期：Complete
• 页码：53-59
• 全文大小：1219 K
• 卷排序：134

文摘

Development of a sensitive and selective ultra-fast liquid chromatography-tandem mass spectrometry (UFLC–MS/MS) method. Application of UFLC–MS/MS for the determination of RA, sal D, LA and sal B in SAFI in rat plasma. The first pharmacokinetic study of salvianolic acid for injection (SAFI). Investigation of dose-dependent pharmacokinetics of SAFI.