A quantitative LC-MS/MS method for simultaneous determination of cocaine and its metabolites in whole blood

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• 作者：Xiabin Chen ; Xirong Zheng ; Kai Ding ; Ziyuan Zhou ; Chang-Guo Zhan ; ^zhan@uky.edu ; Fang Zheng ; ^{fzhen2@uky.edu}
• 关键词：Cocaine ; Alcohol ; Drug metabolism ; SPE ; LC&ndash ; MS/MS
• 刊名：Journal of Pharmaceutical and Biomedical Analysis
• 出版年：2017
• 出版时间：5 February 2017
• 年：2017
• 卷：134
• 期：Complete
• 页码：243-251
• 全文大小：1902 K
• 卷排序：134

文摘

A LC–MS/MS method to simultaneously detect cocaine and 9 metabolites is developed. The method is highly sensitive and reliable for all of the 10 compounds detected. Metabolic profile of cocaine in rats with co-administration of alcohol is determined.