A sensitive LC-MS/MS method for analysis of pericyazine in presence of 7-hydroxypericyazine and pericyazine sulphoxide in human plasma and its application to a comparative bioequivalence study in Chinese healthy volunteers

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• 作者：Hua Lin Cai^a ; ^b ; ¹ ; Yang Deng^a ; ^b ; ¹ ; Ping Fei Fang^a ; ^b ; SiSi Cao^a ; ^b ; Zhen Yan Hou^a ; ^b ; Yan Qin Wu^a ; ^b ; Xue Jiao Chen^a ; Miao Yan^a ; ^b ; ^{yan.miao@126.com} ; BiKui Zhang^a ; ^b ; ^{bikui_zh@126.com}
• 关键词：Pericyazine ; LC&ndash ; MS/MS ; 7-Hydroxypericyazine ; Pericyazine sulphoxide ; Bioequivalence
• 刊名：Journal of Pharmaceutical and Biomedical Analysis
• 出版年：2017
• 出版时间：20 February 2017
• 年：2017
• 卷：135
• 期：Complete
• 页码：67-74
• 全文大小：1385 K
• 卷排序：135

文摘

Significant improvement in sensitivity for pericyazine (PCZ) determination. Investigation on the fragmentation pattern of PCZ and its major metabolites. Application of the LC–MS/MS method in a bioequivalence study for the first time. Firstly study the metabolism of PCZ in Chinese healthy volunteers. Using z-score transformation to normalize the AUC data for comparisons.