G₂/M cell cycle arrest on HT-29 cancer cells and toxicity assessment of triphenylphosphanegold(I) carbonimidothioates, Ph₃PAu[SC(OR) = NPh], R = Me, Et, and iPr, during zebrafish development

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• 作者：Kah Kooi Ooi^a ; ^b ; Chien Ing Yeo^b ; Theventhiran Mahandaran^c ; Kok Pian Ang^a ; Abdah Md Akim^a ; Yoke-Kqueen Cheah^a ; Hoi-Ling Seng^d ; ^{hoilings@sunway.edu.my} ; Edward R.T. Tiekink^b ; ^{edwardt@sunway.edu.my}
• 关键词：Annexin V-FITC ; Recombinant annexin V conjugated to fluorescein isothiocyanate ; APAF-1 ; Apoptotic protease activating factor 1 ; ATR ; Ataxia telangiectasia and Rad3-related ; Bax ; Apoptosis regulator ; Bcl-2 ; B-cell lymphoma 2 ; BIRC-5 ; Baculoviral inhibitor of apoptosis repeat-containing 5/ Survivin ; CCNB1 ; Cyclin B1 ; cdc25C ; Cell division cycle 25C ; CDKN1A ; Cyclin-dependent kinase N1A ; CDK2 ; Cyclin-dependent kinase 2 ; CDK4 ; Cyclin-dependent kinase 4 ; CHEK1/Chk1 ; Checkpoint kinase 1 ; CHEK2/Chk2 ; Ch
• 刊名：Journal of Inorganic Biochemistry
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：166
• 期：Complete
• 页码：173-181
• 全文大小：1604 K
• 卷排序：166

文摘

Phosphanegold(I) carbonimidothioates are potent to HT-29 cells. They induce apoptotic pathways of cell death. HT-29 cells were arrested at the G2/M checkpoint. They inhibit metastasis through Madgrigal™ matrix. Zebrafish tolerated doses up to 1.25 μM.