A Classical Brown Adipose Tissue mRNA Signature Partly Overlaps with Brite in the Supraclavicular Region of Adult Humans

详细信息    查看全文

• 作者：Naja Zenius Jespersen¹ ; ⁷ ; Therese Juhlin Larsen¹ ; ⁷ ; Lone Peijs¹ ; Sø ; ren Daugaard² ; Preben Homø ; e³ ; Annika Loft⁴ ; Jasper de Jong⁵ ; Neha Mathur¹ ; Barbara Cannon⁵ ; Jan Nedergaard⁵ ; Bente Klarlund Pedersen¹ ; Kirsten Mø ; ller¹ ; ⁶ ; Camilla Scheele¹ ; ^{camilla.scheele@gmail.com}
• 刊名：Cell Metabolism
• 出版年：2013
• 出版时间：7 May, 2013
• 年：2013
• 卷：17
• 期：5
• 页码：798-805
• 全文大小：647 K

文摘

| Figures/TablesFigures/Tables | ReferencesReferences

Summary

Human brown adipose tissue (BAT) has been detected in adults but was recently suggested to be of brite/beige origin. We collected BAT from the supraclavicular region in 21 patients undergoing surgery for suspected cancer in the neck area and assessed the gene expression of established murine markers for brown, brite/beige, and white adipocytes. We demonstrate that a classical brown expression signature, including upregulation of miR-206, miR-133b, LHX8, and ZIC1 and downregulation of HOXC8 and HOXC9, coexists with an upregulation of two newly established brite/beige markers, TBX1 and TMEM26. A similar mRNA expression profile was observed when comparing isolated human adipocytes from BAT and white adipose tissue (WAT) depots, differentiated in?vitro. In conclusion, our data suggest that human BAT might consist of both classical brown and recruitable brite adipocytes, an observation important for future considerations on how to induce human BAT.