CBP/p300 Bromodomains Regulate Amyloid-like Protein Aggregation upon Aberrant Lysine Acetylation

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• 作者：Heidi Olzscha¹ ; Oleg Fedorov² ; Benedikt M. Kessler³ ; Stefan Knapp² ; ⁴ ; Nicholas B. La Thangue¹ ; ⁵ ; ^{nick.lathangue@oncology.ox.ac.uk}
• 关键词：acetylation ; aggregation ; amyloid ; bromodomain ; histone deacetylase ; p300 ; CBP ; huntingtin ; proteostasis ; inhibitor
• 刊名：Cell Chemical Biology
• 出版年：2017
• 出版时间：19 January 2017
• 年：2017
• 卷：24
• 期：1
• 页码：9-23
• 全文大小：5702 K
• 卷排序：24

文摘

Aberrant acetylation causes amyloid-like aggregation and disturbs proteostasis p300/CBP bromodomain proteins are involved in the protein aggregation p300/CBP bromodomain inhibitors reverse the cytotoxicity and restore proteostasis Bromodomain inhibitors also decrease pathological huntingtin protein aggregation