Improvement of chondroitinases ABCI stability in natural deep eutectic solvents

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• 作者：Sara Daneshjou^a ; Shima Khodaverdian^b ; Bahareh Dabirmanesh^b ; Fereshteh Rahimi^c ; Somayeh Daneshjoo^a ; Farideh Ghazi^d ; ^{ghazi.f@iums.ac.ir} ; Khosro Khajeh^a ; ^b ; ^{khajeh@modares.ac.ir}
• 关键词：Deep eutectic solvents ; Enzymatic reactions ; cABCI ; Stability ; Activity
• 刊名：Journal of Molecular Liquids
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：227
• 期：Complete
• 页码：21-25
• 全文大小：560 K
• 卷排序：227

文摘

Deep eutectic solvents (DESs) are of great importance in enzymatic reactions. cABCI is a clinical enzyme which is important in the treatment of spinal lesions. Low thermal stability of the enzyme limits its commercial application. Thermal stability of cABCI was investigated in betaine and choline based DESs. DESs exhibited a better media for enhancing cABCI stability at − 20, 4 and 37 °C.