A highly specific ratiometric two-photon fluorescent probe to detect dipeptidyl peptidase IV in plasma and living systems

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• 作者：Li-Wei Zou^a ; ^b ; ¹ ; Ping Wang^a ; ¹ ; Xing-Kai Qian^a ; Lei Feng^c ; Yang Yu^a ; Dan-Dan Wang^a ; Qiang Jin^a ; Jie Hou^c ; Zhi-Hong Liu^d ; Guang-Bo Ge^a ; ^{geguangbo@dicp.ac.cn} ; Ling Yang^b ; ^{ylingdicp@gmail.com}
• 关键词：Dipeptidyl peptidase IV ; Two-photon fluorescent probe ; Cells and tissues imaging ; Inhibitor screening
• 刊名：Biosensors and Bioelectronics
• 出版年：2017
• 出版时间：15 April 2017
• 年：2017
• 卷：90
• 期：Complete
• 页码：283-289
• 全文大小：662 K
• 卷排序：90

文摘

A highly specific two-photon fluorescent probe GP-BAN has been developed. The probe was successfully applied to detect DPP-IV in complex biological samples. The probe could be used for high throughput screening of DPP-IV inhibitors. The probe was successfully used for two-photon imaging of DPP-IV in living cells and tissues.