Tyrosine fluorescence probing of conformational changes in tryptophan-lacking domain of albumins

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• 作者：N.G. Zhdanova^a ; ^{zhdanova@physics.msu.ru} ; E.G. Maksimov^b ; A.M. Arutyunyan^c ; V.V. Fadeev^a ; E.A. Shirshin^a ; ^{shirshin@lid.phys.msu.ru}
• 关键词：Albumin ; Conformational changes ; Tyrosine fluorescence ; Fluorescence lifetime ; Fluorescence spectroscopy
• 刊名：Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy
• 出版年：2017
• 出版时间：5 March 2017
• 年：2017
• 卷：174
• 期：Complete
• 页码：223-229
• 全文大小：879 K
• 卷排序：174

文摘

Tyr fluorescence was used to monitor conformation of albumin with EtOH and GdnHCl. Tyr-Trp fluorescence diagram reveals intermediates in protein folding. Tyrosine fluorescence is sensitive to changes in domain III of albumin.