A simple and sensitive liquid chromatography-tandem mass spectrometry method for trans-ε-viniferin quantification in mouse plasma and its application to a pharmacokinetic study in mice

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• 作者：Jiseon Kim^a ; Jee Sun Min^a ; Doyun Kim^a ; Yu Fen Zheng^a ; Karabasappa Mailar^b ; Won Jun Choi^b ; Choongho Lee^b ; Soo Kyung Bae^a ; ^{baesk@catholic.ac.kr} ; ^{espero97@hanmail.net}
• 关键词：AUC0-t ; total area under the plasma concentration&minus ; time curve from time zero to time t ; AUC0-&infin ; total area under the plasma concentration&minus ; time curve from time zero to time infinity ; F ; bioavailability ; Cl ; total plasma clearance ; Cmax ; peak plasma concentration ; IS ; internal standard ; LC&ndash ; MS/MS ; liquid chromatography&ndash ; tandem mass spectrometry ; LLOQ ; lower limit of quantitation ; QC ; quality control ; RE ; relative error ; RSD ; relative standard deviation ; Vd ; steady-state
• 刊名：Journal of Pharmaceutical and Biomedical Analysis
• 出版年：2017
• 出版时间：5 February 2017
• 年：2017
• 卷：134
• 期：Complete
• 页码：116-121
• 全文大小：647 K
• 卷排序：134

文摘

First LC–MS/MS method for trans-ε-viniferin quantification in mouse plasma. A simple protein precipitation that allowed for efficient/reproducible recovery yields was used. The small plasma volume (10 μl) supports the ability to examine pharmacokinetics in mice.