Structural-conformational aspects of tRNA complexation with chloroethyl nitrosourea derivatives: A molecular modeling and spectroscopic investigation

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• 作者：Shweta Agarwal^a ; ^b ; Gunjan Tyagi^b ; Deepti Chadha^a ; ^b ; Ranjana Mehrotra^a ; ^b ; ^{ranjana@nplindia.org}
• 关键词：CENUs ; Molecular modeling ; FTIR spectroscopy ; CD spectroscopy ; Drug-RNA interaction
• 刊名：Journal of Photochemistry and Photobiology B: Biology
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：166
• 期：Complete
• 页码：1-11
• 全文大小：1910 K
• 卷排序：166

文摘

Interaction of CENUs with tRNA was investigated using spectroscopic techniques. Molecular docking was performed to predict orientation of CENUs binding to tRNA. FTIR analysis suggests CENUs binding with guanine and further crosslink to cytosine CD spectral results support no transition in native A-conformation of tRNA. Absorption spectroscopy specifies weak type of CENU's binding with tRNA.