A combination of photodynamic therapy and chemotherapy displays a differential cytotoxic effect on human metastatic melanoma cells

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• 作者：FA Nsole Biteghe ; LM Davids ; ^{Lester.Davids@uct.ac.za}
• 关键词：Cutaneous melanoma ; Photodynamic therapy ; Dacarbazine ; ABC transporters
• 刊名：Journal of Photochemistry and Photobiology B: Biology
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：166
• 期：Complete
• 页码：18-27
• 全文大小：1211 K
• 卷排序：166

文摘

Treatment of dacarbazine and PDT to overcome melanoma resistance, is proposed. Synergism of dacarbazine and PDT exists in reducing melanoma cell viability. Morphological disruption was observed upon PDT only and PDT + Dacarbazine treatments. ABCG2 transporters contribute to decreasing the self-renewal capacity of melanoma.