Chitosan-based core-shell nanomaterials for pH-triggered release of anticancer drug and near-infrared bioimaging

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• 作者：Lianjiang Tan^a ; ^{ljtan@sjtu.edu.cn} ; ^{tanlianjiang@126.com} ; Ran Huang^b ; Xiaoqiang Li^c ; Shuiping Liu^c ; Yu-Mei Shen^a ; ^{yumeishen@sjtu.edu.cn} ; Zhifeng Shao^d
• 关键词：Chitosan ; Core-shell nanospheres ; pH-triggered drug release ; Antitumor ; NIR bioimaging
• 刊名：Carbohydrate Polymers
• 出版年：2017
• 出版时间：10 February 2017
• 年：2017
• 卷：157
• 期：Complete
• 页码：325-334
• 全文大小：2432 K
• 卷排序：157

文摘

Modified chitosan exhibits pH-responsive structural transformation. Chitosan-based core-shell nanospheres can release DOX triggered by lowered pH. The NIR-fluorescent nanospheres can be monitored in real time by NIR imaging. DOX release from nanospheres can be activated in tumor cells for cancer therapy.