Exceptional memory performance in the Long Life Family Study

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• 作者：S ; ra Barral ; Stephanie Cosentino ; Rosann Costa ; Stacey L. Andersen ; Kaare Christensen ; John H. Eckfeldt ; Anne B. Newman ; Thomas T. Perls ; Michael A. Province ; Evan C. Hadley ; Winifred K. Rossi ; Richard Mayeux ; Long Life Family Study
• 关键词：Long Life Family Study ; Exceptional memory ; Quantitative trait ; Genetic variants
• 刊名：Neurobiology of Aging
• 出版年：2013
• 出版时间：November, 2013
• 年：2013
• 卷：34
• 期：11
• 页码：2445-2448
• 全文大小：322 K

文摘

Research to understand variability at the highest end of the cognitive performance distribution has been scarce. Our aim was to define a cognitive endophenotype based on exceptional episodic memory (EM) performance and to investigate familial aggregation of EM in families from the Long Life Family Study (LLFS). Using a sample of 1911 nondemented offspring of long-lived probands, we created a quantitative phenotype, EM (memory z ¡Ý 1.5), and classified LLFS families as EM and non-EM families based on the number of EM offspring. We then assessed differences in memory performance between LLFS relatives in the parental generation of EM families and those in non-EM families using multivariate analysis adjusted for APOE Apolipoprotein E genotype. LLFS relatives in the proband generation from EM families showed better EM performance than those from non-EM families (¦Â?= 0.74, standard error?= 0.19, p?= 1.4?¡Á 10^?4). We demonstrated that there is a familial correlation of the EM endophenotype, suggesting that genetic variants might influence memory performance in long-lived families.