Analysis of Tear Cytokines and Clinical Correlations in Sj?gren Syndrome Dry Eye Patients and Non-Sj?gren Syndrome Dry Eye Patients

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• 作者：Sang Yeop Lee ; Soo Jung Han ; Sang Min Nam ; Sang Chul Yoon ; Ji Min Ahn ; Tae-Im Kim ; Eung Kweon Kim ; Kyoung Yul Seo
• 刊名：American Journal of Ophthalmology
• 出版年：2013
• 出版时间：August, 2013
• 年：2013
• 卷：156
• 期：2
• 页码：247-253.e1
• 全文大小：835 K

文摘

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Purpose

To compare concentrations of tear cytokines in 3 groups composed of Sj?gren syndrome (SS) dry eye, non-Sj?gren syndrome (non-SS) dry eye, and normal subjects. Correlations between ocular surface parameters and tear cytokines were also investigated.

Design

Prospective cross-sectional study.

Methods

SS dry eye patients (n?= 24; 40 eyes) were diagnosed with primary SS according to the criteria set by the American-European Consensus Group. Non-SS dry eye patients (n?= 25; 40 eyes) and normal subjects (n?= 21; 35 eyes) were also enrolled. Tear concentrations of interleukin (IL)-17, IL-6, IL-10, IL-4, IL-2, interferon ¦Ã (IFN-¦Ã), and tumor necrosis factor ¦Á (TNF-¦Á) were measured by a multiplex immunobead assay. Ocular Surface Disease Index (OSDI), tear film breakup time (TBUT), Schirmer I test, and fluorescein staining scores were obtained from dry eye patients.

Results

All cytokine levels except for IL-2 were highest in the SS group, followed by non-SS dry eye group and control subjects. Concentrations of IL-17, TNF-¦Á, and IL-6 were significantly different among the 3 groups (IL-17: SS > control P < .001, non-SS > control P?= .042, SS > non-SS P < .001; TNF-¦Á: SS > control P?= .006, non-SS > control P?= .034, SS > non-SS P?= .029; IL-6: SS > control P?= .002, non-SS > control P?= .032, SS > non-SS P?= .002). IL-17 was significantly correlated with TBUT (R?=??0.22, P?= .012) and Schirmer I test (R?=??0.36, P?= .027) scores in the SS group. IL-6 was significantly correlated only with TBUT (R?=??0.38, P?= .02) in the non-SS group.

Conclusions

Differences in tear cytokine levels and correlation patterns between SS dry eye and non-SS dry eye patients suggest the involvement of different inflammatory processes as causes of dry eye syndrome.