Placental biomarkers of PAH exposure and glutathione-S-transferase biotransformation enzymes in an obstetric population from Tijuana, Baja California, Mexico

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• 作者：Teresa Dodd-Butera^a ; ^b ; ^f ; ^{tdbutera@csusb.edu} ; Penelope J.E. Quintana^b ; ^{jquintan@mail.sdsu.edu} ; Martha Ramirez-Zetina^c ; ^{martharz8@hotmail.com} ; Ana C. Batista-Castro^c ; ^d ; ^{anabatista101@hotmail.com} ; Maria M. Sierra^b ; ^{sierramer@gmail.com} ; Carolyn Shaputnic^b ; ^g ; ^{cshaputnic@ucsd.edu} ; Maura Garcia-Castillo^e ; ^h ; ^{mauragarcia@gmail.com} ; Sonja Ingmanson^b ; ^{sonejah@yahoo.com} ; Stacy Hull^b ; ^{hulst74@hotmail.com}
• 关键词：Placental biomonitoring ; Maternal-fetal environment ; US-Mexico border ; Polyaromatic hydrocarbons ; Biotransformation enzymes
• 刊名：Environmental Research
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：152
• 期：Complete
• 页码：360-368
• 全文大小：432 K
• 卷排序：152

文摘

Maternal-fetal environment susceptible to toxic exposures at US-Mexico border. Lower serum folate was correlated with higher PAH-DNA adduct levels at birth. Placental DNA adducts in GST mu (-) cord blood were higher than GST(+) genotype. Blood lead levels in Mexican women were higher than reported to NHANES. Cadmium levels in mothers exposed to ETS correlated with total PAH-DNA adducts.