Chemical constituents from the roots of Cynanchum paniculatum and their cytotoxic activity

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• 作者：Chung Sub Kim ; Ju Yeoun Oh ; Sang Un Choi ; Kang Ro Lee
• 关键词：Cynanchum paniculatum ; Asclepiadaceae ; Steroidal glycosides ; Cytotoxicity
• 刊名：Carbohydrate Research
• 出版年：2013
• 出版时间：15 November, 2013
• 年：2013
• 卷：381
• 期：Complete
• 页码：1-5
• 全文大小：343 K

文摘

Two new steroidal saponins, cynanside A (1) and B (2) were isolated together with three known compounds (3-5) from the roots of Cynanchum paniculatum (Bunge) Kitag. The structures of 1 and 2 were elucidated on the basis of spectroscopic analyses, including extensive 2D NMR and acid hydrolysis. We evaluated the cytotoxicity of isolates (1-5) against A549, SK-OV-3, SK-MEL-2, and HCT-15 cell lines in vitro using the SRB bioassay. Compounds 1 and 2 showed selective cytotoxicity against SK-MEL-2 cells with IC₅₀ values of 26.55 and 17.36 ¦ÌM, respectively.