Isocoumarin derivatives from the marine-derived fungus Phoma sp. 135

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• 作者：Mahmoud F. Elsebai^a ; ^b ; ^{elsebai72@yahoo.com" class="auth_mail" title="E-mail the corresponding author} ; Hazem A. Ghabbour^c ; ^d
• 关键词：Chlorinated isocoumarin ; Phoma sp. ; X-ray analysis ; Marine natural products ; Structure elucidation ; Absolute stereochemistry
• 刊名：Tetrahedron Letters
• 出版年：2016
• 出版时间：20 January 2016
• 年：2016
• 卷：57
• 期：3
• 页码：354-356
• 全文大小：375 K

文摘

The dihydro-isocoumarin derivatives 1–2 were isolated from the marine-derived fungus Phoma sp. 135. Structural elucidation was achieved through extensive spectroscopic evaluation including 1D- and 2D-NMR, accurate mass measurements, and single crystal X-ray diffraction analysis. We report herein the structure and absolute configuration of the known compound 1 using X-ray diffraction, and the structural elucidation of the new dihydro-isocoumarin derivative 2.