The homologous conjugate addition of thiols to electron-deficient cyclopropanes catalyzed by a calcium(II) complex

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• 作者：Caroline M. Braun ; Alyssa M. Shema ; Callie C. Dulin ; Kristine A. Nolin
• 关键词：Cyclopropanes ; Homologous conjugate addition ; Calcium catalysis ; Thiol addition
• 刊名：Tetrahedron Letters
• 出版年：2013
• 出版时间：30 October, 2013
• 年：2013
• 卷：54
• 期：44
• 页码：5889-5891
• 全文大小：626 K

文摘

The synthesis of ¦Ã-sulfanyl malonates was achieved through the addition of thiols to electron deficient cyclopropanes. These reactions are catalyzed by calcium acetylacetonate, Ca(acac)₂. A variety of electron rich and electron deficient thiols were added without the need for prior activation or exogenous base. The thiol additions to donor-acceptor cyclopropanes bearing electron-rich and electron-deficient aromatic and heteroaromatic groups proceeded in good to excellent yields.