Deleterious effects in reproduction and developmental immunity elicited by pulmonary iron oxide nanoparticles

详细信息    查看全文

• 作者：Eun-Jung Park^a ; ^{pejtoxic@hanmail.net} ; Uiseok Jeong^b ; Younghun Kim^b ; Byoung-Seok Lee^c ; Myung-Haing Cho^d ; You-Seok Go^e
• 关键词：Iron oxide nanoparticles ; Reproduction ; Immunotoxicity ; Mortality ; Sex ratio
• 刊名：Environmental Research
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：152
• 期：Complete
• 页码：503-513
• 全文大小：2165 K
• 卷排序：152

文摘

FeNPs were single instilled intratracheally to the male and female parent mice. Two female parent mice died at 4 mg/kg dose during pre-mating period. The body weight gain dose-dependently decreased in male and female parent mice. Iron accumulation was observed in the ovary and the testis of FeNP-treated parent mice. The total sex ratio of the offspring mice increased in FeNP-treated parent group.