Chlorhexidine digluconate on chitosan-magnetic iron oxide nanoparticles modified electrode: Electroanalysis and mechanistic insights by computational simulations

详细信息    查看全文

• 作者：Camila P. Sousa^a ; ^{pinheiro.cs@gmail.com}Author Vitae ; Raissa C. de Oliveira^aAuthor Vitae ; Tiago. M. Freire^aAuthor Vitae ; Pierre B.A. Fechine^aAuthor Vitae ; Michele A. Salvador^bAuthor Vitae ; Paula Homem-de-Mello^bAuthor Vitae ; Simone Morais^cAuthor Vitae ; Pedro de Lima-Neto^aAuthor Vitae ; Adriana N. Correia^aAuthor Vitae
• 关键词：Chlorhexidine ; Magnetic nanoparticles ; Chitosan ; Computational simulations ; Pharmaceuticals
• 刊名：Sensors and Actuators B: Chemical
• 出版年：2017
• 出版时间：March 2017
• 年：2017
• 卷：240
• 期：Complete
• 页码：417-425
• 全文大小：1659 K
• 卷排序：240

文摘

An electrochemical sensor was developed to quantify chlorhexidine digluconate (CHD). A modificated GCE with magnetic iron oxide nanoparticles and chitosan was developed. Monte Carlo simulations were performed to give insights on the CHD oxidation process. GCE/Fe3O4/CS exhibited good analytical performance to quantify CHD. GCE/Fe3O4/CS was successfully applied to two CHD commercial formulations.