Synthesis of 3-heteryl substituted pyrrolidine-2,5-diones via catalytic Michael reaction and evaluation of their inhibitory activity against InhA and Mycobacterium tuberculosis

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• 作者：Tetiana Matviiuk ; Giorgia Mori ; Christian Lherbet ; Fr茅d茅ric Rodriguez ; Maria Rosalia Pasca ; Marian Gorichko ; Brigitte Guidetti ; Zoia Voitenko ; Michel Baltas
• 关键词：Succinimide ; Michael addition ; Tuberculosis ; InhA
• 刊名：European Journal of Medicinal Chemistry
• 出版年：7 January, 2014
• 年：2014
• 卷：71
• 期：Complete
• 页码：46-52
• 全文大小：758 K

文摘

In the present paper, we report the synthesis via catalytic Michael reaction and biological results of a series of 3-heteryl substituted pyrrolidine-2,5-dione derivatives as moderate inhibitors against Mycobacterium tuberculosis H37Rv growth. Some of them present also inhibition activities against InhA.