Controllable self-assembly of an amphiphilic drug with 尾-cyclodextrin and 伪-amylase

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• 作者：Shangyang Li ; Pengyao Xing ; Lin Zhang ; Feifei Xin ; Jinhui Nie ; Hailu Wang ; Mingfang Ma ; Yurong Wu ; Aiyou Hao
• 关键词：尾-Cyclodextrin ; Vesicle ; Enzyme-responsive ; Complex ; Drugs
• 刊名：Colloids and Surfaces A: Physicochemical and Engineering Aspects
• 出版年：20 March, 2014
• 年：2014
• 卷：445
• 期：Complete
• 页码：67-74
• 全文大小：3199 K

文摘

Herein, we report a novel responsive assembly system consisting of an amphiphilic drug fenspiride and 尾-cyclodextrin in host-guest approach. Fenspiride molecules can self-assembled into vesicles in aqueous solution. The obtained vesicles were characterized in detail by transmission electron microscopy (TEM), scanning electron microscopy (SEM) and atomic force microscopy (AFM). Furthermore, such a vesicular structure will be destroyed upon the addition of 尾-cyclodextrin due to the formation of inclusion complexes by host-guest interactions. In addition, amylase is a digestive enzyme which can catalyze the breakdown of starch into sugars. Adding 伪-amylase into the system could release fenspiride molecules, and trigger the self-assembly of fenspiride molecules again. It is anticipated that this research will provide widespread applications in the fields of responsive materials and biochemistry related to enzyme-responsive model system and host-guest chemistry.