Evaluation of a Thermosensitive Atelocollagen Punctal Plug Treatment for Dry Eye Disease

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• 作者：Takashi Kojima ; Yukihiro Matsumoto ; Osama M.A. Ibrahim ; Tais Hitomi Wakamatsu ; Murat Dogru ; Kazuo Tsubota
• 刊名：American Journal of Ophthalmology
• 出版年：February, 2014
• 年：2014
• 卷：157
• 期：2
• 页码：311-317.e1
• 全文大小：1127 K

文摘

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Purpose

To evaluate the efficacy of a thermosensitive atelocollagen punctal plug in the treatment of dry eye disease.

Design

Prospective observational case series.

Methods

The thermosensitive atelocollagen punctal plug was warmed at 37 C, 39 C, 41 C, and 43 C to evaluate the appropriate temperature and time for solidification. Dry eye patients were divided into 2 groups according to the preparation method of the atelocollagen punctal plug. In the conventional implantation group, atelocollagen gel was kept at room temperature for 15聽minutes before implantation (27 eyes of 14 patients). In the preheating group, atelocollagen was warmed at 41聽C for 8聽minutes before implantation (23 eyes of 13 dry eye patients). Strip meniscometry, vital stainings, tear film break-up time (BUT), and symptom scores were evaluated before and 1聽month after plug implantation.

Results

In聽vitro experiments revealed that heating at 41聽C for 8聽minutes was sufficient to solidify the gel. The mean fluorescein score in the conventional implantation group significantly improved after treatment (before, 3.5 卤 2.3 points; after, 2.5 卤 0.9 points, P < .05). In the preheating group, the mean fluorescein score (before, 3.7 卤 1.7 points; after, 1.5 卤 1.2 points), strip meniscometry (before, 0.6 卤 0.7聽mm; after, 1.1 卤 0.3聽mm), BUT (before, 3.2 卤 0.7 seconds; after, 4.8 卤 1.0 seconds), and visual analog scale scores (before, 6.6 卤 1.5 points; after, 4.1 卤 0.9 points) significantly improved after treatment (P < .05).

Conclusion

The thermosensitive atelocollagen punctal plug was effective for dry eye treatment. The preheating method was found to be useful to strengthen the efficacy of the thermosensitive atelocollagen punctal plug.