Positron emission tomography imaging of 5-hydroxytryptamine_1B receptors in Parkinson's disease

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• 作者：Andrea Varrone ; Per Svenningsson ; Anton Forsberg ; Katarina Varn盲s ; Mikael Tiger ; Ryuji Nakao ; Christer Halldin ; Lars-G枚ran Nilsson ; Lars Farde
• 关键词：Serotonin ; 5-HT1B ; Parkinson's disease ; Limbic system ; Aging ; High-resolution PET
• 刊名：Neurobiology of Aging
• 出版年：April, 2014
• 年：2014
• 卷：35
• 期：4
• 页码：867-875
• 全文大小：1232 K

文摘

Impairment of the central serotonin system in Parkinson's disease (PD) has been shown postmortem and in聽vivo with positron emission tomography (PET). The aim of this PET study was to examine and compare the availability of the 5-hydroxytryptamine (5-HT)_1B-receptor subtype in patients with PD and age-matched control subjects. Twelve control subjects and 12 PD patients were examined with PET using the 5-HT_1B-radioligand [¹¹C]AZ10419369. In PD patients, 5-HT_1B-receptor availability in the right orbitofrontal cortex was lower than in control subjects. A statistically significant negative correlation between 5-HT_1B-receptor availability and age was obtained for the right temporal cortex in control subjects and for the right midbrain and left parahippocampal gyrus in PD patients. The lower regional 5-HT_1B-receptor availability is in line with previous studies showing a decrease of serotonin imaging markers in PD and corroborates a role of the serotonin system in the pathophysiology of PD. The demonstrated age effect on 5-HT_1B receptors suggest a physiologic and PD-related decline of serotonin function, indicating the importance of controlling for age in clinical studies.