Nigella sativa L. seeds modulate mood, anxiety and cognition in healthy adolescent males

详细信息    查看全文

• 作者：Muhammad Shahdaat Bin Sayeed ; Tahiatul Shams ; Sarder Fahim Hossain ; Md. Rezowanur Rahman ; AGM Mostofa ; Mohammad Fahim Kadir ; Sharif Mahmood ; Md. Asaduzzaman
• 关键词：NS ; Nigella sativa L. seeds ; CVLT-II ; modified California verbal learning test-II ; STAI ; State&ndash ; Trait Anxiety Inventory ; ADHD ; attention deficit hyperactivity disorder ; CONSORT ; consolidated standards of reporting trials ; 5-HT ; 5-hydroxytryptamine ; GABA ; gamma-aminobutyric acid ; 5-HIAA ; 5-hydroxyindoleacetic acid ; NO ; nitric oxide ; SDCR ; short delay cued recall ; SDFR ; short delay free recall ; LDCR ; long delay cued recall ; LDFR ; long delay free recall
• 刊名：Journal of Ethnopharmacology
• 出版年：27 February, 2014
• 年：2014
• 卷：152
• 期：1
• 页码：156-162
• 全文大小：1107 K

文摘

Ethnopharmacological relevance

Previous studies conducted on animals linked consumption of Nigella sativa L. seeds (NS) to decreased anxiety and improved memory. The present study, which was carried out at a boarding school in Bangladesh, was designed to examine probable effect of NS on mood, anxiety and cognition in adolescent human males.

Materials and methods

Forty-eight healthy adolescent human males aged between 14 to 17 years were randomly recruited as volunteers and were randomly split into two groups: A (n=24) and B (n=24). The treatment procedure for group A and B were one capsule of 500 mg placebo and 500 mg NS respectively once daily for four weeks. All the volunteers were assessed for cognition with modified California verbal learning test-II (CVLT-II), mood with Bond-Lader scale and anxiety with State-Trait Anxiety Inventory (STAI) at the beginning and after four weeks of either NS or placebo ingestion.

Results and discussion

No parameter showed statistically significant variation between A and B in measurements in the beginning, but after 4 weeks of one capsule of NS 500 mg intake, there was statistically significant variation of mood within group B but there was not statistically significant variation between group A and B. No significant variation was found in state anxiety within groups and between group A and B but in case of trait anxiety, significant variation was found within group B but not between group A and B. In case of CVLT II, there was significant variation within B in immediate short-term recall at trial 4 and 5 whereas this difference was found only in case of trial 5 between group A and B. Within group B, short term-free recall, long-term free recall and long-term cued recall had statistical difference whereas between group A and B long-term free recall and long-term cued recall had statistical difference. No parameters had significant variation within group A after placebo intake for 4 weeks.

Conclusions

Over the 4 weeks study period, the use of NS as a nutritional supplement been observed to- stabilize mood, decrease anxiety and modulate cognition positively. However, long term study is suggested before using NS extensively.