The microenvironment in T-cell lymphomas: Emerging themes

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• 作者：Philippe Gaulard ; Laurence de Leval
• 关键词：T-cell lymphoma ; Microenvironment ; Angioimmunoblastic T-cell lymphoma ; Folliclar helper T cell ; Macrophages ; Angiogenesis
• 刊名：Seminars in Cancer Biology
• 出版年：February, 2014
• 年：2014
• 卷：24
• 期：Complete
• 页码：49-60
• 全文大小：3321 K

文摘

Peripheral T-cell lymphomas (PTCLs) are heterogeneous and uncommon malignancies characterized by an aggressive clinical course and a mostly poor outcome with current treatment strategies. Despite novel insights into their pathobiology provided by recent genome-wide molecular studies, several entities remain poorly characterized. In addition to the neoplastic cell population, PTCLs have a microenvironment component, composed of non-tumor cells and stroma, which is quantitatively and qualitatively variable, and which may have an effect on their pathological and clinical features. The best example is provided by angioimmunoblastic T-cell lymphoma (AITL), a designation reflecting the typical vascularization and reactive immunoblastic content of the tumor tissues. In this disease, a complex network of interactions between the lymphoma cells and the microenvironment exists, presumably mediated by the neoplastic T cells with follicular helper T-cell properties. A better understanding of the crosstalk between neoplastic T or NK cells and their microenvironment may have important implications for guiding the development of novel therapies.