Enhanced virulence of clade 2.3.2.1 highly pathogenic avian influenza A H5N1 viruses in ferrets

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• 作者：Melissa B. Pearce^a ; Claudia Pappas^a ; Kortney M. Gustin^a ; C. Todd Davis^a ; Mary J. Pantin-Jackwood^b ; David E. Swayne^b ; Taronna R. Maines^a ; Jessica A. Belser^a ; Terrence M. Tumpey^a ; ^tft9@cdc.gov
• 关键词：Pathogenesis ; Ferrets ; Influenza H5N1
• 刊名：Virology
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：502
• 期：Complete
• 页码：114-122
• 全文大小：1483 K
• 卷排序：502

文摘

The relative virulence of 11 H5N1 viruses isolated between 2006 and 2013 were determined. Clade 2.3.2.1b, but not 2.3.2.1a viruses were associated with ferret lethality. Clade 2.3.2.1b viruses possessed the most severe histopathological changes in lung tissues. Molecular correlates of H5N1 virus pathogenicity were assessed.